5NPS

The human O-GlcNAc transferase in complex with a bisubstrate inhibitor

Summary for 5NPS

Entry DOI	10.2210/pdb5nps/pdb
Descriptor	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] propyl hydrogen phosphate, ... (4 entities in total)
Functional Keywords	o-glcnac transferase, gt-b, gt41, rossman-fold, active site, inhibitor, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	81717.10
Authors	Rafie, K.,van Aalten, D. (deposition date: 2017-04-18, release date: 2018-05-16, Last modification date: 2023-03-15)
Primary citation	Rafie, K.,Gorelik, A.,Trapannone, R.,Borodkin, V.S.,van Aalten, D.M.F. Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors. Bioconjug. Chem., 29:1834-1840, 2018 Cited by PubMed: 29723473 DOI: 10.1021/acs.bioconjchem.8b00194 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation