5NPR
The human O-GlcNAc transferase in complex with a thiol-linked bisubstrate inhibitor
Summary for 5NPR
| Entry DOI | 10.2210/pdb5npr/pdb |
| Descriptor | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, bisubstrate inhibitor, POTASSIUM ION, ... (5 entities in total) |
| Functional Keywords | o-glcnac transferase, gt-b, rossman-fold, active site, inhibitor, transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 81675.15 |
| Authors | Rafie, K.,van Aalten, D.M.F. (deposition date: 2017-04-18, release date: 2018-05-16, Last modification date: 2024-01-17) |
| Primary citation | Rafie, K.,Gorelik, A.,Trapannone, R.,Borodkin, V.S.,van Aalten, D.M.F. Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors. Bioconjug. Chem., 29:1834-1840, 2018 Cited by PubMed: 29723473DOI: 10.1021/acs.bioconjchem.8b00194 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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