5NPH
Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5
Summary for 5NPH
Entry DOI | 10.2210/pdb5nph/pdb |
Descriptor | Genome polyprotein, Heavy chain of Fab fragment derived from non-neutralizing antibody DAO5, Light chain of Fab fragment derived from non-neutralizing antibody DAO5, ... (4 entities in total) |
Functional Keywords | envelope glycoprotein, hepatitis c virus, fab fragment, cd81 binding loop, immune system |
Biological source | Mus musculus (house mouse) More |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972 |
Total number of polymer chains | 3 |
Total formula weight | 53026.65 |
Authors | Vasiliauskaite, I.,Rey, F.A.,Krey, T. (deposition date: 2017-04-16, release date: 2017-05-24, Last modification date: 2024-05-01) |
Primary citation | Vasiliauskaite, I.,Owsianka, A.,England, P.,Khan, A.G.,Cole, S.,Bankwitz, D.,Foung, S.K.H.,Pietschmann, T.,Marcotrigiano, J.,Rey, F.A.,Patel, A.H.,Krey, T. Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8:-, 2017 Cited by PubMed: 28512091DOI: 10.1128/mBio.00382-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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