5NP8
PGK1 in complex with CRT0063465 (3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid)
Summary for 5NP8
| Entry DOI | 10.2210/pdb5np8/pdb |
| Descriptor | Phosphoglycerate kinase 1, 3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid, 1,2-ETHANEDIOL, ... (5 entities in total) |
| Functional Keywords | kinase, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 45701.39 |
| Authors | Turnbull, A.P.,Bilsland, A.E.,Liu, Y.,Sumpton, D.,Stevenson, K.,Cairney, C.J.,Roffey, J.,Jenkinson, D.,Keith, W.N. (deposition date: 2017-04-13, release date: 2018-05-16, Last modification date: 2024-01-17) |
| Primary citation | Bilsland, A.E.,Liu, Y.,Turnbull, A.,Sumpton, D.,Stevenson, K.,Cairney, C.J.,Boyd, S.M.,Roffey, J.,Jenkinson, D.,Keith, W.N. A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation. Neoplasia, 21:893-907, 2019 Cited by PubMed: 31401411DOI: 10.1016/j.neo.2019.07.008 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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