5NOS

Structure of cyclophilin A in complex with 3-amino-1H-pyridin-2-one

Summary for 5NOS

Entry DOI	10.2210/pdb5nos/pdb
Descriptor	Peptidyl-prolyl cis-trans isomerase A, 5-azanyl-3~{H}-pyridin-6-one (3 entities in total)
Functional Keywords	ligand complex, beta barrel, prolyl cis/trans isomerase, cytosolic, isomerase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P62937
Total number of polymer chains	1
Total formula weight	18146.62
Authors	Georgiou, C.,Mcnae, I.W.,Ioannidis, H.,Julien, M.,Walkinshaw, M.D. (deposition date: 2017-04-13, release date: 2017-07-12, Last modification date: 2024-01-17)
Primary citation	Georgiou, C.,McNae, I.,Wear, M.,Ioannidis, H.,Michel, J.,Walkinshaw, M. Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders. J. Mol. Biol., 429:2556-2570, 2017 Cited by PubMed: 28673552 DOI: 10.1016/j.jmb.2017.06.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation