5NNG

Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated SRPK1 peptide (K585ac)

5NNG の概要

• エントリーDOI: 10.2210/pdb5nng/pdb
• 分子名称: Bromodomain-containing protein 4, VAG(ALY)YS(ALY)EFFY, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, transcription, complex, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16646.10

構造登録者

Filippakopoulos, P.,Picaud, S.,Newman, J.,Sorrell, F.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Structural Genomics Consortium (SGC) (登録日: 2017-04-08, 公開日: 2018-05-16, 最終更新日: 2024-01-17)

• 主引用文献: Lambert, J.P.,Picaud, S.,Fujisawa, T.,Hou, H.,Savitsky, P.,Uuskula-Reimand, L.,Gupta, G.D.,Abdouni, H.,Lin, Z.Y.,Tucholska, M.,Knight, J.D.R.,Gonzalez-Badillo, B.,St-Denis, N.,Newman, J.A.,Stucki, M.,Pelletier, L.,Bandeira, N.,Wilson, M.D.,Filippakopoulos, P.,Gingras, A.C.; Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.; Mol. Cell, 73:621-638.e17, 2019; PubMed: 30554943; DOI: 10.1016/j.molcel.2018.11.006

実験手法

X-RAY DIFFRACTION (1.2 Å)