5NN5

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with 1-deoxynojirimycin

5NN5 の概要

• エントリーDOI: 10.2210/pdb5nn5/pdb
• 関連するPDBエントリー: 5NN3 5NN4
• 分子名称: Lysosomal alpha-glucosidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glycoside hydrolase, lysosome, glycogen catabolism, pompe disease, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 101073.96

構造登録者

Roig-Zamboni, V.,Cobucci-Ponzano, B.,Iacono, R.,Ferrara, M.C.,Germany, S.,Parenti, G.,Bourne, Y.,Moracci, M. (登録日: 2017-04-08, 公開日: 2017-10-25, 最終更新日: 2024-01-17)

• 主引用文献: Roig-Zamboni, V.,Cobucci-Ponzano, B.,Iacono, R.,Ferrara, M.C.,Germany, S.,Bourne, Y.,Parenti, G.,Moracci, M.,Sulzenbacher, G.; Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease.; Nat Commun, 8:1111-1111, 2017; PubMed: 29061980; DOI: 10.1038/s41467-017-01263-3

実験手法

X-RAY DIFFRACTION (2 Å)