5NN5
Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with 1-deoxynojirimycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysosomal alpha-glucosidase | polymer | 872 | 96978.6 | 1 | UniProt (P10253) Pfam (PF00088) Pfam (PF13802) Pfam (PF01055) Pfam (PF21365) | Homo sapiens (Human) | Acid maltase,Aglucosidase alfa |
| 2 | B, F (B, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 3 | C (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 6 | G (A) | 1-DEOXYNOJIRIMYCIN | non-polymer | 163.2 | 1 | Chemie (NOJ) | |||
| 7 | H, I, J, K (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 8 | L, M, N, O, P... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 9 | R, S, T, U, V... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 10 | Y (A) | water | water | 18.0 | 773 | Chemie (HOH) |
Sequence modifications
A: 81 - 952 (UniProt: P10253)
| PDB | External Database | Details |
|---|---|---|
| Arg 199 | His 199 | conflict |
| His 223 | Arg 223 | conflict |
| Ile 780 | Val 780 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 96978.6 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2900.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1194.6 | |
| All* | Total formula weight | 101074.0 |
