5NMM
The structure of the polo-box domain (PBD) of Plk1 in complex with Alpha-Bromo-3-Iodotoluene.
Summary for 5NMM
| Entry DOI | 10.2210/pdb5nmm/pdb |
| Descriptor | Serine/threonine-protein kinase PLK1, Alpha-Bromo-3-Iodotoluene (3 entities in total) |
| Functional Keywords | plk1, pbd1, mitosis, small molecule, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: P53350 |
| Total number of polymer chains | 1 |
| Total formula weight | 27582.09 |
| Authors | Kunciw, D.L.,Rossmann, M.,Stokes, J.E.,De Fusco, C.,Spring, D.R.,Hyvonen, M. (deposition date: 2017-04-06, release date: 2018-02-21, Last modification date: 2023-09-13) |
| Primary citation | Sharma, P.,Mahen, R.,Rossmann, M.,Stokes, J.E.,Hardwick, B.,Huggins, D.J.,Emery, A.,Kunciw, D.L.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. Sci Rep, 9:15930-15930, 2019 Cited by PubMed: 31685831DOI: 10.1038/s41598-019-50702-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
Download full validation report
