5NLK
Crystal structure of CREBBP bromodomain complexd with US13A
Summary for 5NLK
Entry DOI | 10.2210/pdb5nlk/pdb |
Descriptor | CREB-binding protein, ~{N}-[3-acetamido-5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]phenyl]furan-2-carboxamide (3 entities in total) |
Functional Keywords | inhibitor, bromodomain, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 1 |
Total formula weight | 14672.81 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2017-04-04, release date: 2018-02-21, Last modification date: 2024-01-17) |
Primary citation | Batiste, L.,Unzue, A.,Dolbois, A.,Hassler, F.,Wang, X.,Deerain, N.,Zhu, J.,Spiliotopoulos, D.,Nevado, C.,Caflisch, A. Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple). ACS Cent Sci, 4:180-188, 2018 Cited by PubMed: 29532017DOI: 10.1021/acscentsci.7b00401 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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