5NKY

Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain

Summary for 5NKY

Entry DOI	10.2210/pdb5nky/pdb
Descriptor	Vitamin D3 receptor A, SRC1, (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{S})-1-[(2~{R},5~{S})-5-(2-oxidanylpropan-2-yl)oxolan-2-yl]ethyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
Functional Keywords	gene regulation
Biological source	Danio rerio (Zebrafish) More
Cellular location	Nucleus: Q9PTN2
Total number of polymer chains	2
Total formula weight	36281.39
Authors	Rochel, N.,Belorusova, A.Y. (deposition date: 2017-04-03, release date: 2017-05-24, Last modification date: 2024-01-17)
Primary citation	Belorusova, A.Y.,Martinez, A.,Gandara, Z.,Gomez, G.,Fall, Y.,Rochel, N. Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain. Eur J Med Chem, 134:86-96, 2017 Cited by PubMed: 28399453 DOI: 10.1016/j.ejmech.2017.03.081 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.096 Å)

Structure validation