5NIH

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution.

5NIH の概要

• エントリーDOI: 10.2210/pdb5nih/pdb
• 分子名称: Glutamate receptor 2, SULFATE ION, (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid, ... (7 entities in total)
• 機能のキーワード: ionotropic glutamate receptor, ampa receptor, ligand-binding domain, glua2, glur2, agonist, membrane protein
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P19491
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59962.49

構造登録者

Laulumaa, S.,Frydenvang, K.A.,Kastrup, J.S. (登録日: 2017-03-24, 公開日: 2017-07-26, 最終更新日: 2024-01-17)

• 主引用文献: Mllerud, S.,Pinto, A.,Marconi, L.,Frydenvang, K.,Thorsen, T.S.,Laulumaa, S.,Venskutonyte, R.,Winther, S.,Moral, A.M.C.,Tamborini, L.,Conti, P.,Pickering, D.S.,Kastrup, J.S.; Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.; ACS Chem Neurosci, 8:2056-2064, 2017; PubMed: 28691798; DOI: 10.1021/acschemneuro.7b00201

実験手法

X-RAY DIFFRACTION (1.3 Å)