5NGZ

Ube2T in complex with fragment EM04

Summary for 5NGZ

Entry DOI	10.2210/pdb5ngz/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 T, 1-(1,3-benzothiazol-2-yl)methanamine (3 entities in total)
Functional Keywords	ubiquitin-conjugating enzyme ube2t, fragment screening, fanconi anemia pathway, dna repair, ligase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q9NPD8
Total number of polymer chains	1
Total formula weight	22718.10
Authors	Morreale, F.E.,Bortoluzzi, A.,Chaugule, V.K.,Arkinson, C.,Walden, H.,Ciulli, A. (deposition date: 2017-03-21, release date: 2017-05-03, Last modification date: 2024-01-17)
Primary citation	Morreale, F.E.,Bortoluzzi, A.,Chaugule, V.K.,Arkinson, C.,Walden, H.,Ciulli, A. Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening. J. Med. Chem., 60:4093-4098, 2017 Cited by PubMed: 28437106 DOI: 10.1021/acs.jmedchem.7b00147 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation