5NGZ

Ube2T in complex with fragment EM04

5NGZ の概要

• エントリーDOI: 10.2210/pdb5ngz/pdb
• 分子名称: Ubiquitin-conjugating enzyme E2 T, 1-(1,3-benzothiazol-2-yl)methanamine (3 entities in total)
• 機能のキーワード: ubiquitin-conjugating enzyme ube2t, fragment screening, fanconi anemia pathway, dna repair, ligase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q9NPD8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22718.10

構造登録者

Morreale, F.E.,Bortoluzzi, A.,Chaugule, V.K.,Arkinson, C.,Walden, H.,Ciulli, A. (登録日: 2017-03-21, 公開日: 2017-05-03, 最終更新日: 2024-01-17)

• 主引用文献: Morreale, F.E.,Bortoluzzi, A.,Chaugule, V.K.,Arkinson, C.,Walden, H.,Ciulli, A.; Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.; J. Med. Chem., 60:4093-4098, 2017; PubMed: 28437106; DOI: 10.1021/acs.jmedchem.7b00147

実験手法

X-RAY DIFFRACTION (2.4 Å)