5NGV

CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM

5NGV の概要

• エントリーDOI: 10.2210/pdb5ngv/pdb
• 分子名称: Activin receptor type-2B, anti-human ActRIIB mAb BYM338 heavy-chain, anti-human ActRIIB mAb BYM338 light-chain, ... (5 entities in total)
• 機能のキーワード: three-finger toxin fold, antibody fv fragment, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37744.70

構造登録者

Rondeau, J.-M.,Lehmann, S. (登録日: 2017-03-20, 公開日: 2017-11-15, 最終更新日: 2024-01-17)

• 主引用文献: Morvan, F.,Rondeau, J.-M.,Zou, C.,Minetti, G.,Scheufler, C.,Scharenberg, M.,Jacobi, C.,Brebbia, P.,Ritter, V.,Toussaint, G.,Koelbing, C.,Leber, X.,Schilb, A.,Witte, F.,Lehmann, S.,Koch, E.,Geisse, S.,Glass, D.J.,Lach-Trifilieff, E.; Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.; Proc. Natl. Acad. Sci. U.S.A., 114:12448-12453, 2017; PubMed: 29109273; DOI: 10.1073/pnas.1707925114

実験手法

X-RAY DIFFRACTION (2 Å)