5NGB
X-Ray Diffraction Crystal Structure of the murine PI3K p110delta in complex with a pan inhibitor
Summary for 5NGB
Entry DOI | 10.2210/pdb5ngb/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 3-[[4-(2-morpholin-4-yl-4-oxidanylidene-3~{H}-quinolin-8-yl)-1,2,3-triazol-1-yl]methyl]benzoic acid (2 entities in total) |
Functional Keywords | pi3k p110, transferase |
Biological source | Mus musculus (House Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 124744.51 |
Authors | Berndt, A.,Williams, R.L. (deposition date: 2017-03-17, release date: 2017-09-13, Last modification date: 2024-01-17) |
Primary citation | Pirali, T.,Ciraolo, E.,Aprile, S.,Massarotti, A.,Berndt, A.,Griglio, A.,Serafini, M.,Mercalli, V.,Landoni, C.,Campa, C.C.,Margaria, J.P.,Silva, R.L.,Grosa, G.,Sorba, G.,Williams, R.,Hirsch, E.,Tron, G.C. Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs. ChemMedChem, 12:1542-1554, 2017 Cited by PubMed: 28857471DOI: 10.1002/cmdc.201700340 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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