5NGB

X-Ray Diffraction Crystal Structure of the murine PI3K p110delta in complex with a pan inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	polymer	1079	124313.1	1	UniProt (Q3UDT3) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) UniProt (by SIFTS) (O35904)	Mus musculus (House Mouse)	Putative uncharacterized protein
2	B (A)	3-[[4-(2-morpholin-4-yl-4-oxidanylidene-3~{H}-quinolin-8-yl)-1,2,3-triazol-1-yl]methyl]benzoic acid	non-polymer		431.4	1	Chemie (8WH)

Sequence modifications

A: -6 - 1044 (UniProt: Q3UDT3)

PDB	External Database	Details
Met -34	-	initiating methionine
Ser -33	-	expression tag
Tyr -32	-	expression tag
Tyr -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
Asp -24	-	expression tag
Tyr -23	-	expression tag
Asp -22	-	expression tag
Ile -21	-	expression tag
Pro -20	-	expression tag
Thr -19	-	expression tag
Thr -18	-	expression tag
Glu -17	-	expression tag
Asn -16	-	expression tag
Leu -15	-	expression tag
Tyr -14	-	expression tag
Phe -13	-	expression tag
Gln -12	-	expression tag
Gly -11	-	expression tag
Ala -10	-	expression tag
Met -9	-	expression tag
Asp -8	-	expression tag
Leu -7	-	expression tag
Glu 99	-	insertion
Asn 100	-	insertion
Leu 101	-	insertion
Tyr 102	-	insertion
Phe 103	-	insertion
Gln 104	-	insertion
Gly 105	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	124313.1
Non-Polymers*	Number of molecules	1
	Total formula weight	431.4
All*	Total formula weight	124744.5

*Water molecules are not included.