5NG5

multi-drug efflux; membrane transport; RND superfamily; Drug resistance

5NG5 の概要

• エントリーDOI: 10.2210/pdb5ng5/pdb
• EMDBエントリー: 3636
• 分子名称: Multidrug efflux pump subunit AcrA, Outer membrane protein TolC, Multidrug efflux pump subunit AcrB, ... (5 entities in total)
• 機能のキーワード: multi-drug efflux; membrane transport; rnd superfamily; drug resistance, membrane protein
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell inner membrane ; Lipid- anchor : P0AE06; Cell outer membrane ; Multi-pass membrane protein : P02930; Cell inner membrane ; Multi- pass membrane protein : P31224; Cell inner membrane ; Single-pass membrane protein : P0AAW9
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 760715.11

構造登録者

Wang, Z.,Fan, G.,Hryc, C.F.,Blaza, J.N.,Serysheva, I.I.,Schmid, M.F.,Chiu, W.,Luisi, B.F.,Du, D. (登録日: 2017-03-16, 公開日: 2017-04-19, 最終更新日: 2017-08-02)

• 主引用文献: Wang, Z.,Fan, G.,Hryc, C.F.,Blaza, J.N.,Serysheva, I.I.,Schmid, M.F.,Chiu, W.,Luisi, B.F.,Du, D.; An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump.; Elife, 6:-, 2017; PubMed: 28355133; DOI: 10.7554/eLife.24905

実験手法

ELECTRON MICROSCOPY (6.5 Å)