5NFH
Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor
Summary for 5NFH
Entry DOI | 10.2210/pdb5nfh/pdb |
Descriptor | Methionyl-tRNA synthetase, putative, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor, complex, drug discovery |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 2 |
Total formula weight | 122598.45 |
Authors | Robinson, D.A.,Eadsforth, T.C.,Shepherd, S.M.,Torrie, L.S.,De Rycker, M.,Gilbert, I.H. (deposition date: 2017-03-14, release date: 2017-10-11, Last modification date: 2024-01-17) |
Primary citation | Torrie, L.S.,Brand, S.,Robinson, D.A.,Ko, E.J.,Stojanovski, L.,Simeons, F.R.C.,Wyllie, S.,Thomas, J.,Ellis, L.,Osuna-Cabello, M.,Epemolu, O.,Nuhs, A.,Riley, J.,MacLean, L.,Manthri, S.,Read, K.D.,Gilbert, I.H.,Fairlamb, A.H.,De Rycker, M. Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani. ACS Infect Dis, 3:718-727, 2017 Cited by PubMed: 28967262DOI: 10.1021/acsinfecdis.7b00047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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