5NFH

Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor

5NFH の概要

• エントリーDOI: 10.2210/pdb5nfh/pdb
• 分子名称: Methionyl-tRNA synthetase, putative, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor, complex, drug discovery
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122598.45

構造登録者

Robinson, D.A.,Eadsforth, T.C.,Shepherd, S.M.,Torrie, L.S.,De Rycker, M.,Gilbert, I.H. (登録日: 2017-03-14, 公開日: 2017-10-11, 最終更新日: 2024-01-17)

• 主引用文献: Torrie, L.S.,Brand, S.,Robinson, D.A.,Ko, E.J.,Stojanovski, L.,Simeons, F.R.C.,Wyllie, S.,Thomas, J.,Ellis, L.,Osuna-Cabello, M.,Epemolu, O.,Nuhs, A.,Riley, J.,MacLean, L.,Manthri, S.,Read, K.D.,Gilbert, I.H.,Fairlamb, A.H.,De Rycker, M.; Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.; ACS Infect Dis, 3:718-727, 2017; PubMed: 28967262; DOI: 10.1021/acsinfecdis.7b00047

実験手法

X-RAY DIFFRACTION (2.8 Å)