5NF5

Structure of GluK1 ligand-binding domain (S1S2) in complex with CIP-AS at 2.85 A resolution

Summary for 5NF5

• Entry DOI: 10.2210/pdb5nf5/pdb
• Descriptor: Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, CHLORIDE ION, (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, ... (5 entities in total)
• Functional Keywords: ionotropic glutamate receptor, kainate receptor, ligand-binding domain, gluk1, glur5, agonist, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P22756
• Total number of polymer chains: 2
• Total formula weight: 59152.55

Authors

Frydenvang, K.,Venskutonyte, R.,Thorsen, T.S.,Kastrup, J.S. (deposition date: 2017-03-13, release date: 2017-07-26, Last modification date: 2024-01-17)

• Primary citation: Mllerud, S.,Pinto, A.,Marconi, L.,Frydenvang, K.,Thorsen, T.S.,Laulumaa, S.,Venskutonyte, R.,Winther, S.,Moral, A.M.C.,Tamborini, L.,Conti, P.,Pickering, D.S.,Kastrup, J.S.; Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.; ACS Chem Neurosci, 8:2056-2064, 2017; PubMed: 28691798; DOI: 10.1021/acschemneuro.7b00201

Experimental method

X-RAY DIFFRACTION (2.85 Å)