Summary for 5NEV
| Entry DOI | 10.2210/pdb5nev/pdb |
| Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, 4-[[6-(3-phenylphenyl)-7~{H}-purin-2-yl]amino]benzenesulfonamide, ... (4 entities in total) |
| Functional Keywords | cdk2 cyclin a, cdk2 selective transferase, transferase |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P20248 |
| Total number of polymer chains | 4 |
| Total formula weight | 129590.05 |
| Authors | Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Noble, M.E.M.,Newell, D.R.,Turner, D.,Sivaprakasam, M.,Wang, L.Z.,Wong, C.,Golding, B.T.,Griffin, R.J.,Cano, G. (deposition date: 2017-03-12, release date: 2017-03-29, Last modification date: 2024-01-17) |
| Primary citation | Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.,Golding, B.T.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Newell, D.R.,Noble, M.E.,Sivaprakasam, M.,Tudhope, S.J.,Turner, D.M.,Wang, L.Z.,Wedge, S.R.,Wong, C.,Griffin, R.J.,Endicott, J.A.,Cano, C. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J. Med. Chem., 60:1746-1767, 2017 Cited by PubMed: 28005359DOI: 10.1021/acs.jmedchem.6b01254 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.97 Å) |
Structure validation
Download full validation report
