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5NEV

CDK2/Cyclin A in complex with compound 73

Replaces:  5LQE
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, CCyclin-dependent kinase 2polymer30334467.92UniProt (P24941)
Pfam (PF00069)
In PDB
Homo sapiens (Human)Cell division protein kinase 2,p33 protein kinase
2B, DCyclin-A2polymer26029884.62UniProt (P20248)
Pfam (PF00134)
Pfam (PF02984)
In PDB
Homo sapiens (Human)Cyclin-A,Cyclin A
3A, C4-[[6-(3-phenylphenyl)-7~{H}-purin-2-yl]amino]benzenesulfonamidenon-polymer442.52Chemie (72L)
4waterwater18.016Chemie (HOH)
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDBExternal DatabaseDetails
Gly -4-expression tag
Pro -3-expression tag
Leu -2-expression tag
Gly -1-expression tag
Ser 0-expression tag
B, D: 174 - 432 (UniProt: P20248)
PDBExternal DatabaseDetails
Met 173-initiating methionine
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight128705.1
Non-Polymers*Number of molecules2
Total formula weight885.0
All*Total formula weight129590.0
*Water molecules are not included.

217705

PDB entries from 2024-03-27

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