5NDX

The bacterial orthologue of Human a-L-iduronidase does not need N-glycan post-translational modifications to be catalytically competent: Crystallography and QM/MM insights into Mucopolysaccharidosis I

Summary for 5NDX

• Entry DOI: 10.2210/pdb5ndx/pdb
• Descriptor: Glycosyl hydrolase, SULFATE ION, (2~{R},3~{S},4~{S},5~{R},6~{S})-6-(4-methyl-2-oxidanylidene-chromen-7-yl)oxy-3,4,5-tris(oxidanyl)oxane-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: human a-l-iduronidase, mucopolysaccharidosis i, catalytic itinerary, reaction coordinates, catalytic mechanism, n-glycosylation site, rhizobium leguminosarum, iduronidase, hydrolase
• Biological source: Rhizobium leguminosarum bv. trifolii
• Total number of polymer chains: 1
• Total formula weight: 70640.35

Authors

Raich, L.,Valero-Gonzalez, J.,Castro-Lopez, J.,Millan, C.,Jimenez-Garcia, M.J.,Nieto, P.,Uson, I.,Hurtado-Guerrero, R.,Rovira, C. (deposition date: 2017-03-09, release date: 2018-07-11, Last modification date: 2024-05-01)

• Primary citation: Raich, L.,Valero-Gonzalez, J.,Castro-Lopez, J.,Millan, C.,Jimenez-Garcia, M.J.,Nieto, P.,Uson, I.,Hurtado-Guerrero, R.,Rovira, C.; The bacterial orthologue of Human a-L-iduronidase does not need N-glycan post-translational modifications to be catalytically competent: Crystallography and QM/MM insights into Mucopolysaccharidosis I.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)