5NDB

Crystal structure of metallo-beta-lactamase SPM-1 complexed with cyclobutanone inhibitor

Summary for 5NDB

• Entry DOI: 10.2210/pdb5ndb/pdb
• Descriptor: Beta-lactamase IMP-1, ZINC ION, GLYCEROL, ... (9 entities in total)
• Functional Keywords: lactamase, inhibitor, cyclobutanone, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 57883.29

Authors

Hinchliffe, P.,Spencer, J. (deposition date: 2017-03-08, release date: 2018-01-17, Last modification date: 2024-01-17)

• Primary citation: Abboud, M.I.,Kosmopoulou, M.,Krismanich, A.P.,Johnson, J.W.,Hinchliffe, P.,Brem, J.,Claridge, T.D.W.,Spencer, J.,Schofield, C.J.,Dmitrienko, G.I.; Cyclobutanone Mimics of Intermediates in Metallo-beta-Lactamase Catalysis.; Chemistry, 24:5734-5737, 2018; PubMed: 29250863; DOI: 10.1002/chem.201705886

Experimental method

X-RAY DIFFRACTION (2.38 Å)