5NCY
mPI3Kd IN COMPLEX WITH inh1
Summary for 5NCY
Entry DOI | 10.2210/pdb5ncy/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total) |
Functional Keywords | mi3kd, inhibitor, complex pi3k, transferase |
Biological source | Mus musculus (Mouse) |
Cellular location | Cytoplasm : O35904 |
Total number of polymer chains | 1 |
Total formula weight | 108364.29 |
Authors | Petersen, J. (deposition date: 2017-03-06, release date: 2017-06-21, Last modification date: 2024-05-01) |
Primary citation | Perry, M.W.D.,Bjorhall, K.,Bonn, B.,Carlsson, J.,Chen, Y.,Eriksson, A.,Fredlund, L.,Hao, H.,Holden, N.S.,Karabelas, K.,Lindmark, H.,Liu, F.,Pemberton, N.,Petersen, J.,Rodrigo Blomqvist, S.,Smith, R.W.,Svensson, T.,Terstiege, I.,Tyrchan, C.,Yang, W.,Zhao, S.,Oster, L. Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration. J. Med. Chem., 60:5057-5071, 2017 Cited by PubMed: 28520415DOI: 10.1021/acs.jmedchem.7b00401 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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