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5NCP

ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-12]-OH

Summary for 5NCP
Entry DOI10.2210/pdb5ncp/pdb
DescriptorProtein enabled homolog, (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, NITRATE ION, ... (5 entities in total)
Functional Keywordsproline-rich motif, ena/vasp inhibitor, actin, protein-protein interaction, cell adhesion
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight13526.52
Authors
Barone, M.,Roske, Y. (deposition date: 2017-03-06, release date: 2018-03-28, Last modification date: 2024-01-31)
Primary citationBarone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R.
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020
Cited by
PubMed: 33184177
DOI: 10.1073/pnas.2007213117
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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