5NBF

ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-3]-OH

Summary for 5NBF

Entry DOI	10.2210/pdb5nbf/pdb
Descriptor	Protein enabled homolog, (3~{S},6~{S},7~{R},9~{a}~{R})-6-[[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonylamino]-7-methyl-5-oxidanylidene-1,2,3,6,7,9~{a}-hexahydropyrrolo[1,2-a]azepine-3-carboxylic acid, SULFATE ION, ... (5 entities in total)
Functional Keywords	proline-rich motif, ena/vasp inhibitor, actin, protein-protein interaction, cell adhesion
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13452.50
Authors	Barone, M.,Roske, Y. (deposition date: 2017-03-01, release date: 2017-05-24, Last modification date: 2024-01-31)
Primary citation	Barone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R. Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020 Cited by PubMed: 33184177 DOI: 10.1073/pnas.2007213117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation