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5NB7

Complement factor D

Summary for 5NB7
Entry DOI10.2210/pdb5nb7/pdb
DescriptorComplement factor D, DIMETHYL SULFOXIDE, 1-[2-[(1~{R},3~{S},5~{R})-3-[(6-bromanylpyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]indazole-3-carboxamide, ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceHomo sapiens (Human)
Cellular locationSecreted: P00746
Total number of polymer chains1
Total formula weight25236.55
Authors
Mac Sweeney, A.,Ostermann, N. (deposition date: 2017-03-01, release date: 2017-06-28, Last modification date: 2024-01-17)
Primary citationLorthiois, E.,Anderson, K.,Vulpetti, A.,Rogel, O.,Cumin, F.,Ostermann, N.,Steinbacher, S.,Mac Sweeney, A.,Delgado, O.,Liao, S.M.,Randl, S.,Rudisser, S.,Dussauge, S.,Fettis, K.,Kieffer, L.,de Erkenez, A.,Yang, L.,Hartwieg, C.,Argikar, U.A.,La Bonte, L.R.,Newton, R.,Kansara, V.,Flohr, S.,Hommel, U.,Jaffee, B.,Maibaum, J.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem., 60:5717-5735, 2017
Cited by
PubMed: 28621538
DOI: 10.1021/acs.jmedchem.7b00425
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.33 Å)
Structure validation

217705

數據於2024-03-27公開中

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