5NAL
The crystal structure of inhibitor-15 covalently bound to PDE6D
Summary for 5NAL
Entry DOI | 10.2210/pdb5nal/pdb |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, ~{N}4-[(4-chlorophenyl)methyl]-~{N}1-(cyclohexylmethyl)-~{N}4-cyclopentyl-~{N}1-[(~{Z})-4-[(~{E})-methyliminomethyl]-5-oxidanyl-hex-4-enyl]benzene-1,4-disulfonamide (3 entities in total) |
Functional Keywords | lipid binding protein, woodward's reagent k, covalent protein labeling at glutamic acids, arl2 mediated cargo release |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : O43924 |
Total number of polymer chains | 1 |
Total formula weight | 18105.31 |
Authors | Fansa, E.K.,Martin-Gago, P.,Waldmann, H.,Wittinghofer, A. (deposition date: 2017-02-28, release date: 2017-05-10, Last modification date: 2024-01-17) |
Primary citation | Martin-Gago, P.,Fansa, E.K.,Winzker, M.,Murarka, S.,Janning, P.,Schultz-Fademrecht, C.,Baumann, M.,Wittinghofer, A.,Waldmann, H. Covalent Protein Labeling at Glutamic Acids. Cell Chem Biol, 24:589-597.e5, 2017 Cited by PubMed: 28434875DOI: 10.1016/j.chembiol.2017.03.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report