5NAF

Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain

Summary for 5NAF

• Entry DOI: 10.2210/pdb5naf/pdb
• Descriptor: F-box-like/WD repeat-containing protein TBL1XR1, Methyl-CpG-binding protein 2, GLYCEROL, ... (4 entities in total)
• Functional Keywords: wd40 domain ; protein-peptide complex; transcriptional repressor; rett syndrome, transcription
• Biological source: Mus musculus (Mouse); More
• Cellular location: Nucleus : Q8BHJ5 Q9Z2D6
• Total number of polymer chains: 6
• Total formula weight: 183227.82

Authors

Kruusvee, V.,Cook, A.G. (deposition date: 2017-02-27, release date: 2017-03-29, Last modification date: 2024-01-17)

• Primary citation: Kruusvee, V.,Lyst, M.J.,Taylor, C.,Tarnauskaite, Z.,Bird, A.P.,Cook, A.G.; Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.; Proc. Natl. Acad. Sci. U.S.A., 114:E3243-E3250, 2017; PubMed: 28348241; DOI: 10.1073/pnas.1700731114

Experimental method

X-RAY DIFFRACTION (2.493 Å)