5N9P
ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-1]-NH2
Summary for 5N9P
Entry DOI | 10.2210/pdb5n9p/pdb |
Descriptor | Protein enabled homolog, Ac-[2-Cl-F]-PP-[ProM-1]-NH2, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | proline-rich motif, ena/vasp inhibitor, actin, protein-protein interaction, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 27200.48 |
Authors | Barone, M.,Roske, Y. (deposition date: 2017-02-26, release date: 2017-06-14, Last modification date: 2024-01-31) |
Primary citation | Barone, M.,Muller, M.,Chiha, S.,Ren, J.,Albat, D.,Soicke, A.,Dohmen, S.,Klein, M.,Bruns, J.,van Dinther, M.,Opitz, R.,Lindemann, P.,Beerbaum, M.,Motzny, K.,Roske, Y.,Schmieder, P.,Volkmer, R.,Nazare, M.,Heinemann, U.,Oschkinat, H.,Ten Dijke, P.,Schmalz, H.G.,Kuhne, R. Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc.Natl.Acad.Sci.USA, 117:29684-29690, 2020 Cited by PubMed: 33184177DOI: 10.1073/pnas.2007213117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report