5N9N

Crystal structure of human Protein kinase CK2 catalytic subunit in complex with the ATP-competitive, tight-binding dibenzofuran inhibitor TF85 (4a)

Summary for 5N9N

Entry DOI	10.2210/pdb5n9n/pdb
Related	5N9K 5N9L
Descriptor	Casein kinase II subunit alpha, (4~{Z})-7,9-bis(chloranyl)-4-[[(4-methoxyphenyl)amino]methylidene]-8-oxidanyl-1,2-dihydrodibenzofuran-3-one, ACETATE ION, ... (5 entities in total)
Functional Keywords	protein kinase, ck2, casein kinase 2, protein phosphorylation, atp-competitive inhititors, dibenzofuran derivatives, transferase, tight-binding inhibitors
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	41226.68
Authors	Schnitzler, A.,Gratz, A.,Bollacke, A.,Weyrich, M.,Kucklaender, U.,Wuensch, B.,Goetz, C.,Niefind, K.,Jose, J. (deposition date: 2017-02-25, release date: 2018-02-28, Last modification date: 2024-01-17)
Primary citation	Schnitzler, A.,Gratz, A.,Bollacke, A.,Weyrich, M.,Kucklander, U.,Wunsch, B.,Gotz, C.,Niefind, K.,Jose, J. A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors. Pharmaceuticals, 11:-, 2018 Cited by PubMed: 29462988 DOI: 10.3390/ph11010023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.841 Å)

Structure validation