5N7W

Computationally designed functional antibody

Summary for 5N7W

DescriptorAntibody Fragment Heavy Chain, Antibody Fragment Light Chain, Interleukin-17A, ... (4 entities in total)
Functional Keywordscomputationally designed antibody il17, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight129625.71
Authors
Hargreaves, D.,Breed, J. (deposition date: 2017-02-21, release date: 2018-11-14, Last modification date: 2018-12-05)
Primary citation
Nimrod, G.,Fischman, S.,Austin, M.,Herman, A.,Keyes, F.,Leiderman, O.,Hargreaves, D.,Strajbl, M.,Breed, J.,Klompus, S.,Minton, K.,Spooner, J.,Buchanan, A.,Vaughan, T.J.,Ofran, Y.
Computational Design of Epitope-Specific Functional Antibodies.
Cell Rep, 25:2121-2131.e5, 2018
PubMed: 30463010 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2018.10.081
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.96 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2524 0.8% 4.0% 5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5n7w
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Molmil generated image of 5n7w
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Molmil generated image of 5n7w
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