5N7T

Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5,6-dichloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

5N7T の概要

• エントリーDOI: 10.2210/pdb5n7t/pdb
• 分子名称: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: kmo, kynurenine 3-monooxygenase, oxidoreductase
• 由来する生物種: Pseudomonas fluorescens
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104409.94

構造登録者

Rowland, P. (登録日: 2017-02-21, 公開日: 2017-06-14)

• 主引用文献: Liddle, J.,Beaufils, B.,Binnie, M.,Bouillot, A.,Denis, A.A.,Hann, M.M.,Haslam, C.P.,Holmes, D.S.,Hutchinson, J.P.,Kranz, M.,McBride, A.,Mirguet, O.,Mole, D.J.,Mowat, C.G.,Pal, S.,Rowland, P.,Trottet, L.,Uings, I.J.,Walker, A.L.,Webster, S.P.; The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.; Bioorg. Med. Chem. Lett., 27:2023-2028, 2017; PubMed: 28336141; DOI: 10.1016/j.bmcl.2017.02.078

実験手法

X-RAY DIFFRACTION (1.81 Å)