5N7E

Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).

Summary for 5N7E

Entry DOI	10.2210/pdb5n7e/pdb
Descriptor	Mb(Bcr-DH_4), Breakpoint cluster region protein (3 entities in total)
Functional Keywords	dbl-homology, monobody, bcr-abl, transferase, signaling protein
Biological source	synthetic construct More
Cellular location	Cell junction, synapse, postsynaptic cell membrane, postsynaptic density : P11274
Total number of polymer chains	2
Total formula weight	35022.68
Authors	Reckel, S.,Reynaud, A.,Pojer, F.,Hantschel, O. (deposition date: 2017-02-20, release date: 2017-12-27, Last modification date: 2024-01-17)
Primary citation	Reckel, S.,Gehin, C.,Tardivon, D.,Georgeon, S.,Kukenshoner, T.,Lohr, F.,Koide, A.,Buchner, L.,Panjkovich, A.,Reynaud, A.,Pinho, S.,Gerig, B.,Svergun, D.,Pojer, F.,Guntert, P.,Dotsch, V.,Koide, S.,Gavin, A.C.,Hantschel, O. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8:2101-2101, 2017 Cited by PubMed: 29235475 DOI: 10.1038/s41467-017-02313-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.647 Å)

Structure validation