5N70

CRYSTAL STRUCTURE OF MATURE CATHEPSIN D FROM THE TICK IXODES RICINUS (IRCD1) IN COMPLEX WITH THE N-TERMINAL OCTAPEPTIDE OF THE PROPEPTID

Summary for 5N70

Entry DOI	10.2210/pdb5n70/pdb
Descriptor	Putative cathepsin d, ALA-PHE-ARG-ILE-PRO-LEU-THR-ARG (3 entities in total)
Functional Keywords	hydrolase
Biological source	Ixodes ricinus (castor bean tick) More
Total number of polymer chains	2
Total formula weight	38590.30
Authors	Brynda, J.,Hanova, I.,Hobizalova, R.,Mares, M. (deposition date: 2017-02-17, release date: 2017-12-27, Last modification date: 2018-03-28)
Primary citation	Hanova, I.,Brynda, J.,Houstecka, R.,Alam, N.,Sojka, D.,Kopacek, P.,Maresova, L.,Vondrasek, J.,Horn, M.,Schueler-Furman, O.,Mares, M. Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite. Cell Chem Biol, 25:318-329.e4, 2018 Cited by PubMed: 29396291 DOI: 10.1016/j.chembiol.2018.01.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation