5N6C

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate

Summary for 5N6C

Entry DOI	10.2210/pdb5n6c/pdb
Descriptor	D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	dehydrogenase, serine metabolism, enzymology, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	65788.90
Authors	Unterlass, J.E.,Basle, A.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (deposition date: 2017-02-14, release date: 2017-11-22, Last modification date: 2024-01-17)
Primary citation	Unterlass, J.E.,Wood, R.J.,Basle, A.,Tucker, J.,Cano, C.,Noble, M.M.E.,Curtin, N.J. Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget, 8:104478-104491, 2017 Cited by PubMed: 29262655 DOI: 10.18632/oncotarget.22327 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation