5N6C

Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate

5N6C の概要

• エントリーDOI: 10.2210/pdb5n6c/pdb
• 分子名称: D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: dehydrogenase, serine metabolism, enzymology, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65788.90

構造登録者

Unterlass, J.E.,Basle, A.,Tucker, J.,Cano, C.,Noble, M.E.M.,Curtin, N.J. (登録日: 2017-02-14, 公開日: 2017-11-22, 最終更新日: 2024-01-17)

• 主引用文献: Unterlass, J.E.,Wood, R.J.,Basle, A.,Tucker, J.,Cano, C.,Noble, M.M.E.,Curtin, N.J.; Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).; Oncotarget, 8:104478-104491, 2017; PubMed: 29262655; DOI: 10.18632/oncotarget.22327

実験手法

X-RAY DIFFRACTION (2.3 Å)