5N5H

Crystal structure of metallo-beta-lactamase VIM-1 in complex with ML302F inhibitor

Summary for 5N5H

Entry DOI	10.2210/pdb5n5h/pdb
Descriptor	Beta-lactamase VIM-1, ZINC ION, (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, ... (4 entities in total)
Functional Keywords	lactamase, inhibitor, carbapenemase, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	27313.14
Authors	Salimraj, R.,Hinchliffe, P.,Spencer, J. (deposition date: 2017-02-14, release date: 2018-03-07, Last modification date: 2024-01-17)
Primary citation	Salimraj, R.,Hinchliffe, P.,Kosmopoulou, M.,Tyrrell, J.M.,Brem, J.,van Berkel, S.S.,Verma, A.,Owens, R.J.,McDonough, M.A.,Walsh, T.R.,Schofield, C.J.,Spencer, J. Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-beta-lactamases. FEBS J., 286:169-183, 2019 Cited by PubMed: 30430727 DOI: 10.1111/febs.14695 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation