5N49
BRPF2 in complex with Compound 7
Summary for 5N49
Entry DOI | 10.2210/pdb5n49/pdb |
Descriptor | Bromodomain-containing protein 1, 2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione (3 entities in total) |
Functional Keywords | bromodomain, chemical probe, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O95696 |
Total number of polymer chains | 2 |
Total formula weight | 31877.40 |
Authors | Bouche, L.,Christ, C.D.,Siegel, S.,Fernandez-Montalvan, A.E.,Holton, S.J.,Fedorov, O.,ter Laak, A.,Sugawara, T.,Stoeckigt, D.,Tallant, C.,Bennett, J.,Monteiro, O.,Saez, L.D.,Siejka, P.,Meier, J.,Puetter, V.,Weiske, J.,Mueller, S.,Huber, K.V.M.,Hartung, I.V.,Haendler, B. (deposition date: 2017-02-10, release date: 2017-05-03, Last modification date: 2024-05-08) |
Primary citation | Bouche, L.,Christ, C.D.,Siegel, S.,Fernandez-Montalvan, A.E.,Holton, S.J.,Fedorov, O.,Ter Laak, A.,Sugawara, T.,Stockigt, D.,Tallant, C.,Bennett, J.,Monteiro, O.,Diaz-Saez, L.,Siejka, P.,Meier, J.,Putter, V.,Weiske, J.,Muller, S.,Huber, K.V.M.,Hartung, I.V.,Haendler, B. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60:4002-4022, 2017 Cited by PubMed: 28402630DOI: 10.1021/acs.jmedchem.7b00306 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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