5N3W

Crystal structure of LTA4H bound to a selective inhibitor against LTB4 generation

Summary for 5N3W

Entry DOI	10.2210/pdb5n3w/pdb
Descriptor	Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total)
Functional Keywords	hydrolase, inflammation
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P09960
Total number of polymer chains	1
Total formula weight	71017.95
Authors	Wong, C.T.,Low, C.M.,Snelgrove, R.J.,Hare, S.A. (deposition date: 2017-02-09, release date: 2017-03-29, Last modification date: 2024-01-17)
Primary citation	Low, C.M.,Akthar, S.,Patel, D.F.,Loser, S.,Wong, C.T.,Jackson, P.L.,Blalock, J.E.,Hare, S.A.,Lloyd, C.M.,Snelgrove, R.J. The development of novel LTA4H modulators to selectively target LTB4 generation. Sci Rep, 7:44449-44449, 2017 Cited by PubMed: 28303931 DOI: 10.1038/srep44449 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation