5N2M

Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue

Summary for 5N2M

• Entry DOI: 10.2210/pdb5n2m/pdb
• Descriptor: Bromodomain-containing protein 4, propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transcription, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15647.02

Authors

Tallant, C.,Slavish, P.J.,Siejka, P.,Bharatham, N.,Shadrick, W.R.,Chai, S.,Young, B.M.,Boyd, V.A.,Heroven, C.,Wiggers, H.J.,Picaud, S.,Fedorov, O.,Krojer, T.,Chen, T.,Lee, R.E.,Guy, R.K.,Shelat, A.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2017-02-07, release date: 2018-02-28, Last modification date: 2024-01-17)

• Primary citation: Tallant, C.,Slavish, P.J.,Siejka, P.,Bharatham, N.,Shadrick, W.R.,Chai, S.,Young, B.M.,Boyd, V.A.,Heroven, C.,Wiggers, H.J.,Picaud, S.,Fedorov, O.,Krojer, T.,Chen, T.,Lee, R.E.,Guy, R.K.,Shelat, A.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.54 Å)