5N2M

Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 8J2 A 201

Chain	Residue
A	TRP81
A	HOH372
A	HOH426
A	HOH431
A	HOH436
A	PHE83
A	LYS91
A	LEU94
A	ASN140
A	ASP145
A	ILE146
A	HOH308
A	HOH314

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site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 202

Chain	Residue
A	LEU71
A	LYS72
A	TRP75
A	LYS111
A	HOH356

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site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 203

Chain	Residue
A	PRO56
A	LYS57
A	TYR98
A	LYS102
A	HOH327
A	HOH386
A	HOH420

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

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