5N27

X-ray structure of human heavy chain ferritin (apo form)

5N27 の概要

• エントリーDOI: 10.2210/pdb5n27/pdb
• 分子名称: Ferritin heavy chain, CHLORIDE ION, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: ferritin, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21531.62

構造登録者

Ferraro, G.,Merlino, A. (登録日: 2017-02-07, 公開日: 2017-08-02, 最終更新日: 2024-01-17)

主引用文献

Ferraro, G.,Ciambellotti, S.,Messori, L.,Merlino, A.
Cisplatin Binding Sites in Human H-Chain Ferritin.
Inorg Chem, 56:9064-9070, 2017

PubMed Abstract: The aim of this work is to identify the cisplatin binding sites on human H-chain ferritin. High-resolution X-ray crystallography reveals that cisplatin binds four distinct protein sites, that is, the side chains of His136 and Lys68, the side chain of His105, the side chain of Cys90 and the side chain of Cys102. These Pt binding sites are compared with those observed for the adduct that cisplatin forms upon encapsulation within horse spleen L-chain ferritin (87% identity with human L-chain ferritin).

PubMed: 28737381
DOI: 10.1021/acs.inorgchem.7b01072

実験手法

X-RAY DIFFRACTION (1.74 Å)