5N25
Crystal structure of human carbonic anhydrase II in complex with the inhibitor 4-Pyridin-3-yl-benzenesulfonamide
Summary for 5N25
Entry DOI | 10.2210/pdb5n25/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 4-pyridin-3-ylbenzenesulfonamide, ... (5 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29915.11 |
Authors | Ferraroni, M.,Supuran, C.T.,Scozzafava, A.,Carta, F. (deposition date: 2017-02-07, release date: 2017-12-27, Last modification date: 2024-01-17) |
Primary citation | Ferraroni, M.,Cornelio, B.,Sapi, J.,Supuran, C.T.,Scozzafava, A. Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms Inorg.Chim.Acta., 470:128-132, 2018 Cited by DOI: 10.1016/j.ica.2017.03.038PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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