5N17

First Bromodomain (BD1) from Candida albicans Bdf1 bound to a dibenzothiazepinone (compound 3)

Summary for 5N17

• Entry DOI: 10.2210/pdb5n17/pdb
• Descriptor: Bromodomain-containing factor 1, (2~{S})-~{N}-(5-methyl-6-oxidanylidene-benzo[b][1,4]benzothiazepin-2-yl)oxolane-2-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: bromodomain, transcription
• Biological source: Candida albicans (Yeast)
• Cellular location: Nucleus : Q5A4W8
• Total number of polymer chains: 2
• Total formula weight: 31975.07

Authors

Mietton, F.,Ferri, E.,Champleboux, M.,Zala, N.,Maubon, D.,Zhou, Y.,Harbut, M.,Spittler, D.,Garnaud, C.,Courcon, M.,Chauvon, M.,d'Enfer, C.,Kashemirov, B.A.,Hull, M.,Cornet, M.,McKenna, C.E.,Govin, J.,Petosa, C. (deposition date: 2017-02-05, release date: 2017-05-31, Last modification date: 2024-01-17)

• Primary citation: Mietton, F.,Ferri, E.,Champleboux, M.,Zala, N.,Maubon, D.,Zhou, Y.,Harbut, M.,Spittler, D.,Garnaud, C.,Courcon, M.,Chauvel, M.,d'Enfert, C.,Kashemirov, B.A.,Hull, M.,Cornet, M.,McKenna, C.E.,Govin, J.,Petosa, C.; Selective BET bromodomain inhibition as an antifungal therapeutic strategy.; Nat Commun, 8:15482-15482, 2017; PubMed: 28516956; DOI: 10.1038/ncomms15482

Experimental method

X-RAY DIFFRACTION (1.6 Å)