5N09

Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11

Summary for 5N09

Entry DOI	10.2210/pdb5n09/pdb
Descriptor	Envelope Glycoprotein E, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 - Heavy chain, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 - Light chain, ... (6 entities in total)
Functional Keywords	immune system-viral protein complex, viral protein, membrane fusion, class 2 fusion protein, dengue virus, broadly neutralizing antibody, fab fragment, immune system/viral protein
Biological source	Dengue virus 2 More
Total number of polymer chains	6
Total formula weight	204195.82
Authors	Duquerroy, S.,Rouvinski, A.,Guardado-Calvo, P.,Vaney, M.-C.,Sharma, A.,Rey, F. (deposition date: 2017-02-02, release date: 2017-06-07, Last modification date: 2024-01-17)
Primary citation	Rouvinski, A.,Dejnirattisai, W.,Guardado-Calvo, P.,Vaney, M.C.,Sharma, A.,Duquerroy, S.,Supasa, P.,Wongwiwat, W.,Haouz, A.,Barba-Spaeth, G.,Mongkolsapaya, J.,Rey, F.A.,Screaton, G.R. Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope. Nat Commun, 8:15411-15411, 2017 Cited by PubMed: 28534525 DOI: 10.1038/ncomms15411 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.9 Å)

Structure validation