5N09

Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11

5N09 の概要

• エントリーDOI: 10.2210/pdb5n09/pdb
• 分子名称: Envelope Glycoprotein E, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 - Heavy chain, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 - Light chain, ... (6 entities in total)
• 機能のキーワード: immune system-viral protein complex, viral protein, membrane fusion, class 2 fusion protein, dengue virus, broadly neutralizing antibody, fab fragment, immune system/viral protein
• 由来する生物種: Dengue virus 2; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 204195.82

構造登録者

Duquerroy, S.,Rouvinski, A.,Guardado-Calvo, P.,Vaney, M.-C.,Sharma, A.,Rey, F. (登録日: 2017-02-02, 公開日: 2017-06-07, 最終更新日: 2024-01-17)

• 主引用文献: Rouvinski, A.,Dejnirattisai, W.,Guardado-Calvo, P.,Vaney, M.C.,Sharma, A.,Duquerroy, S.,Supasa, P.,Wongwiwat, W.,Haouz, A.,Barba-Spaeth, G.,Mongkolsapaya, J.,Rey, F.A.,Screaton, G.R.; Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope.; Nat Commun, 8:15411-15411, 2017; PubMed: 28534525; DOI: 10.1038/ncomms15411

実験手法

X-RAY DIFFRACTION (3.9 Å)