5MZV

IL-23:IL-23R:Nb22E11 complex

5MZV の概要

• エントリーDOI: 10.2210/pdb5mzv/pdb
• 分子名称: Interleukin-12 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-23 subunit alpha, ... (11 entities in total)
• 機能のキーワード: cytokine, inflammation, extracellular, fibronectin type iii
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 117955.87

構造登録者

Bloch, Y.,Savvides, S.N. (登録日: 2017-02-01, 公開日: 2018-01-03, 最終更新日: 2024-01-17)

• 主引用文献: Bloch, Y.,Bouchareychas, L.,Merceron, R.,Skladanowska, K.,Van den Bossche, L.,Detry, S.,Govindarajan, S.,Elewaut, D.,Haerynck, F.,Dullaers, M.,Adamopoulos, I.E.,Savvides, S.N.; Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.; Immunity, 48:45-58.e6, 2018; PubMed: 29287995; DOI: 10.1016/j.immuni.2017.12.008

実験手法

X-RAY DIFFRACTION (2.8 Å)